Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease
Identifieur interne : 002830 ( Main/Corpus ); précédent : 002829; suivant : 002831Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease
Auteurs : M K York ; M. Dulay ; A. Macias ; H S Levin ; R. Grossman ; R. Simpson ; J. JankovicSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2008-07.
Abstract
Background: We investigated the cognitive and psychiatric outcome 6 months after bilateral subthalamic nucleus deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD) using a disease control group. Methods: 23 patients who underwent DBS were compared with 28 medically treated patients with PD at baseline and at 6 months for neuropsychological measures. In addition to the group outcomes, we report reliable change indices (RCI) and a dementia caseness analysis. Results: Patients who underwent DBS demonstrated a significant decline in verbal memory compared with the control group (p<0.003), and trends for decline on oral information processing, including verbal fluency, timed transcription and word naming. Patients who underwent DBS demonstrated declines in attention, set shifting and semantic fluency but these changes were similar to the rate of decline in the PD group. RCI indicated that patients who underwent DBS demonstrated clinically significant declines in verbal fluency (p<0.01) and inhibition of a dominant response (p<0.003), with trends for declines in set shifting (p<0.02) and verbal long term recall (p<0.08), indicative of frontostriatal dysfunction. Patients who underwent DBS did not demonstrate significant changes in depression, anxiety or psychological distress scores. The caseness analysis revealed that one of the patients who underwent DBS (4%) converted to dementia over 6 months compared with none of the PD controls. Conclusions: Our findings demonstrated that patients who underwent DBS experienced declines in verbal recall and trends for declines in oral information processing 6 months following surgery, even when good motor outcome was achieved. Potential candidates should be counselled about the risk of mild frontostriatal cognitive declines following DBS to weigh the risks and benefits of surgery.
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DOI: 10.1136/jnnp.2007.118786
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Macias</name><affiliation><mods:affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Levin, H S" sort="Levin, H S" uniqKey="Levin H" first="H S" last="Levin">H S Levin</name><affiliation><mods:affiliation>Baylor College of Medicine, Department of Physical Medicine and Rehabilitation, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Grossman, R" sort="Grossman, R" uniqKey="Grossman R" first="R" last="Grossman">R. Grossman</name><affiliation><mods:affiliation>The Methodist Hospital Neurological Institute, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Simpson, R" sort="Simpson, R" uniqKey="Simpson R" first="R" last="Simpson">R. Simpson</name><affiliation><mods:affiliation>The Methodist Hospital Neurological Institute, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J. Jankovic</name><affiliation><mods:affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:729C25B07A55F6210579AD319210C9EB9E3FB761</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1136/jnnp.2007.118786</idno><idno type="url">https://api.istex.fr/document/729C25B07A55F6210579AD319210C9EB9E3FB761/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002830</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease</title><author><name sortKey="York, M K" sort="York, M K" uniqKey="York M" first="M K" last="York">M K York</name><affiliation><mods:affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Dulay, M" sort="Dulay, M" uniqKey="Dulay M" first="M" last="Dulay">M. Dulay</name><affiliation><mods:affiliation>Baylor College of Medicine, Department of Neurosurgery, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Macias, A" sort="Macias, A" uniqKey="Macias A" first="A" last="Macias">A. Macias</name><affiliation><mods:affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Levin, H S" sort="Levin, H S" uniqKey="Levin H" first="H S" last="Levin">H S Levin</name><affiliation><mods:affiliation>Baylor College of Medicine, Department of Physical Medicine and Rehabilitation, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Grossman, R" sort="Grossman, R" uniqKey="Grossman R" first="R" last="Grossman">R. Grossman</name><affiliation><mods:affiliation>The Methodist Hospital Neurological Institute, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Simpson, R" sort="Simpson, R" uniqKey="Simpson R" first="R" last="Simpson">R. Simpson</name><affiliation><mods:affiliation>The Methodist Hospital Neurological Institute, Houston, Texas, USA</mods:affiliation></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J. Jankovic</name><affiliation><mods:affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2008-07">2008-07</date><biblScope unit="volume">79</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="789">789</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">729C25B07A55F6210579AD319210C9EB9E3FB761</idno><idno type="DOI">10.1136/jnnp.2007.118786</idno><idno type="href">jnnp-79-789.pdf</idno><idno type="ArticleID">jn118786</idno><idno type="PMID">17965146</idno><idno type="local">jnnp;79/7/789</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background: We investigated the cognitive and psychiatric outcome 6 months after bilateral subthalamic nucleus deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD) using a disease control group. Methods: 23 patients who underwent DBS were compared with 28 medically treated patients with PD at baseline and at 6 months for neuropsychological measures. In addition to the group outcomes, we report reliable change indices (RCI) and a dementia caseness analysis. Results: Patients who underwent DBS demonstrated a significant decline in verbal memory compared with the control group (p<0.003), and trends for decline on oral information processing, including verbal fluency, timed transcription and word naming. Patients who underwent DBS demonstrated declines in attention, set shifting and semantic fluency but these changes were similar to the rate of decline in the PD group. RCI indicated that patients who underwent DBS demonstrated clinically significant declines in verbal fluency (p<0.01) and inhibition of a dominant response (p<0.003), with trends for declines in set shifting (p<0.02) and verbal long term recall (p<0.08), indicative of frontostriatal dysfunction. Patients who underwent DBS did not demonstrate significant changes in depression, anxiety or psychological distress scores. The caseness analysis revealed that one of the patients who underwent DBS (4%) converted to dementia over 6 months compared with none of the PD controls. Conclusions: Our findings demonstrated that patients who underwent DBS experienced declines in verbal recall and trends for declines in oral information processing 6 months following surgery, even when good motor outcome was achieved. Potential candidates should be counselled about the risk of mild frontostriatal cognitive declines following DBS to weigh the risks and benefits of surgery.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>M K York</name><affiliations><json:string>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>M Dulay</name><affiliations><json:string>Baylor College of Medicine, Department of Neurosurgery, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>A Macias</name><affiliations><json:string>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>H S Levin</name><affiliations><json:string>Baylor College of Medicine, Department of Physical Medicine and Rehabilitation, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>R Grossman</name><affiliations><json:string>The Methodist Hospital Neurological Institute, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>R Simpson</name><affiliations><json:string>The Methodist Hospital Neurological Institute, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>J Jankovic</name><affiliations><json:string>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Research papers</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Memory disorders (neurology)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Stroke</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Memory disorders (psychiatry)</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Background: We investigated the cognitive and psychiatric outcome 6 months after bilateral subthalamic nucleus deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD) using a disease control group. Methods: 23 patients who underwent DBS were compared with 28 medically treated patients with PD at baseline and at 6 months for neuropsychological measures. In addition to the group outcomes, we report reliable change indices (RCI) and a dementia caseness analysis. Results: Patients who underwent DBS demonstrated a significant decline in verbal memory compared with the control group (p>0.003), and trends for decline on oral information processing, including verbal fluency, timed transcription and word naming. Patients who underwent DBS demonstrated declines in attention, set shifting and semantic fluency but these changes were similar to the rate of decline in the PD group. RCI indicated that patients who underwent DBS demonstrated clinically significant declines in verbal fluency (p>0.01) and inhibition of a dominant response (p>0.003), with trends for declines in set shifting (p>0.02) and verbal long term recall (p>0.08), indicative of frontostriatal dysfunction. Patients who underwent DBS did not demonstrate significant changes in depression, anxiety or psychological distress scores. The caseness analysis revealed that one of the patients who underwent DBS (4%) converted to dementia over 6 months compared with none of the PD controls. Conclusions: Our findings demonstrated that patients who underwent DBS experienced declines in verbal recall and trends for declines in oral information processing 6 months following surgery, even when good motor outcome was achieved. Potential candidates should be counselled about the risk of mild frontostriatal cognitive declines following DBS to weigh the risks and benefits of surgery.</abstract><qualityIndicators><score>8</score><pdfVersion>1.2</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1866</abstractCharCount><pdfWordCount>5126</pdfWordCount><pdfCharCount>36675</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>270</abstractWordCount></qualityIndicators><title>Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s 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bibliographiques récupérées via GROBID" name="ISTEX-API (INIST-CNRS)"></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>BMJ</p></availability><date>2007-10-26</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease</title><author><persName><forename type="first">M K</forename><surname>York</surname></persName><affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">M</forename><surname>Dulay</surname></persName><affiliation>Baylor College of Medicine, Department of Neurosurgery, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">A</forename><surname>Macias</surname></persName><affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">H S</forename><surname>Levin</surname></persName><affiliation>Baylor College of Medicine, Department of Physical Medicine and Rehabilitation, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">R</forename><surname>Grossman</surname></persName><affiliation>The Methodist Hospital Neurological Institute, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">R</forename><surname>Simpson</surname></persName><affiliation>The Methodist Hospital Neurological Institute, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">J</forename><surname>Jankovic</surname></persName><affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</affiliation></author></analytic><monogr><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="pISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2008-07"></date><biblScope unit="volume">79</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="789">789</biblScope></imprint></monogr><idno type="istex">729C25B07A55F6210579AD319210C9EB9E3FB761</idno><idno type="DOI">10.1136/jnnp.2007.118786</idno><idno type="href">jnnp-79-789.pdf</idno><idno type="ArticleID">jn118786</idno><idno type="PMID">17965146</idno><idno type="local">jnnp;79/7/789</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007-10-26</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Background: We investigated the cognitive and psychiatric outcome 6 months after bilateral subthalamic nucleus deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD) using a disease control group. Methods: 23 patients who underwent DBS were compared with 28 medically treated patients with PD at baseline and at 6 months for neuropsychological measures. In addition to the group outcomes, we report reliable change indices (RCI) and a dementia caseness analysis. Results: Patients who underwent DBS demonstrated a significant decline in verbal memory compared with the control group (p<0.003), and trends for decline on oral information processing, including verbal fluency, timed transcription and word naming. Patients who underwent DBS demonstrated declines in attention, set shifting and semantic fluency but these changes were similar to the rate of decline in the PD group. RCI indicated that patients who underwent DBS demonstrated clinically significant declines in verbal fluency (p<0.01) and inhibition of a dominant response (p<0.003), with trends for declines in set shifting (p<0.02) and verbal long term recall (p<0.08), indicative of frontostriatal dysfunction. Patients who underwent DBS did not demonstrate significant changes in depression, anxiety or psychological distress scores. The caseness analysis revealed that one of the patients who underwent DBS (4%) converted to dementia over 6 months compared with none of the PD controls. Conclusions: Our findings demonstrated that patients who underwent DBS experienced declines in verbal recall and trends for declines in oral information processing 6 months following surgery, even when good motor outcome was achieved. Potential candidates should be counselled about the risk of mild frontostriatal cognitive declines following DBS to weigh the risks and benefits of surgery.</p></abstract><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Memory disorders (neurology)</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Stroke</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Memory disorders (psychiatry)</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-10-26">Created</change><change when="2008-07">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-14">References 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abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">jn118786</article-id><article-id pub-id-type="doi">10.1136/jnnp.2007.118786</article-id><article-id pub-id-type="other">jnnp;79/7/789</article-id><article-id pub-id-type="other">jnnp;jnnp.2007.118786</article-id><article-id pub-id-type="pmid">17965146</article-id><article-id pub-id-type="other">789</article-id><article-id pub-id-type="other">jnnp.2007.118786</article-id><article-categories><subj-group subj-group-type="heading"><subject content-type="original">Research papers</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Memory disorders (neurology)</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Stroke</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Memory disorders (psychiatry)</subject></subj-group></article-categories><title-group><article-title>Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease</article-title><alt-title alt-title-type="running-head">Research paper</alt-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>York</surname><given-names>M K</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Dulay</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Macias</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Levin</surname><given-names>H S</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Grossman</surname><given-names>R</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Simpson</surname><given-names>R</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Jankovic</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Baylor College of Medicine, Department of Physical Medicine and Rehabilitation, Houston, Texas, USA</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Baylor College of Medicine, Department of Neurosurgery, Houston, Texas, USA</addr-line></aff><aff id="aff4"><label>4</label><addr-line>The Methodist Hospital Neurological Institute, Houston, Texas, USA</addr-line></aff><author-notes><corresp>Dr M K York, Baylor College of Medicine, Department of Neurology, 6501 Fannin, NB302, Houston, Texas 77030, USA; <email xlink:type="simple">myork@bcm.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2008</year></pub-date><pub-date pub-type="epub-original"><day>26</day><month>10</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>26</day><month>10</month><year>2007</year></pub-date><volume>79</volume><volume-id pub-id-type="other">79</volume-id><volume-id pub-id-type="other">79</volume-id><issue>7</issue><issue-id pub-id-type="other">jnnp;79/7</issue-id><issue-id pub-id-type="other">7</issue-id><issue-id pub-id-type="other">79/7</issue-id><fpage>789</fpage><history><date date-type="received"><day>19</day><month>2</month><year>2007</year></date><date date-type="rev-recd"><day>5</day><month>6</month><year>2007</year></date><date date-type="accepted"><day>19</day><month>10</month><year>2007</year></date></history><permissions><copyright-statement>2008 BMJ Publishing Group</copyright-statement><copyright-year>2008</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-79-789.pdf"></self-uri><abstract><sec><title>Background:</title><p>We investigated the cognitive and psychiatric outcome 6 months after bilateral subthalamic nucleus deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD) using a disease control group.</p></sec><sec><title>Methods:</title><p>23 patients who underwent DBS were compared with 28 medically treated patients with PD at baseline and at 6 months for neuropsychological measures. In addition to the group outcomes, we report reliable change indices (RCI) and a dementia caseness analysis.</p></sec><sec><title>Results:</title><p>Patients who underwent DBS demonstrated a significant decline in verbal memory compared with the control group (p<0.003), and trends for decline on oral information processing, including verbal fluency, timed transcription and word naming. Patients who underwent DBS demonstrated declines in attention, set shifting and semantic fluency but these changes were similar to the rate of decline in the PD group. RCI indicated that patients who underwent DBS demonstrated clinically significant declines in verbal fluency (p<0.01) and inhibition of a dominant response (p<0.003), with trends for declines in set shifting (p<0.02) and verbal long term recall (p<0.08), indicative of frontostriatal dysfunction. Patients who underwent DBS did not demonstrate significant changes in depression, anxiety or psychological distress scores. The caseness analysis revealed that one of the patients who underwent DBS (4%) converted to dementia over 6 months compared with none of the PD controls.</p></sec><sec><title>Conclusions:</title><p>Our findings demonstrated that patients who underwent DBS experienced declines in verbal recall and trends for declines in oral information processing 6 months following surgery, even when good motor outcome was achieved. Potential candidates should be counselled about the risk of mild frontostriatal cognitive declines following DBS to weigh the risks and benefits of surgery.</p></sec></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease</title></titleInfo><name type="personal"><namePart type="given">M K</namePart><namePart type="family">York</namePart><affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Dulay</namePart><affiliation>Baylor College of Medicine, Department of Neurosurgery, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Macias</namePart><affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H S</namePart><namePart type="family">Levin</namePart><affiliation>Baylor College of Medicine, Department of Physical Medicine and Rehabilitation, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Grossman</namePart><affiliation>The Methodist Hospital Neurological Institute, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Simpson</namePart><affiliation>The Methodist Hospital Neurological Institute, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Jankovic</namePart><affiliation>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><genre>hwp-journal-coll</genre><topic>Memory disorders (neurology)</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Stroke</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Memory disorders (psychiatry)</topic></subject><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2008-07</dateIssued><dateCreated encoding="w3cdtf">2007-10-26</dateCreated><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Background: We investigated the cognitive and psychiatric outcome 6 months after bilateral subthalamic nucleus deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD) using a disease control group. Methods: 23 patients who underwent DBS were compared with 28 medically treated patients with PD at baseline and at 6 months for neuropsychological measures. In addition to the group outcomes, we report reliable change indices (RCI) and a dementia caseness analysis. Results: Patients who underwent DBS demonstrated a significant decline in verbal memory compared with the control group (p<0.003), and trends for decline on oral information processing, including verbal fluency, timed transcription and word naming. Patients who underwent DBS demonstrated declines in attention, set shifting and semantic fluency but these changes were similar to the rate of decline in the PD group. RCI indicated that patients who underwent DBS demonstrated clinically significant declines in verbal fluency (p<0.01) and inhibition of a dominant response (p<0.003), with trends for declines in set shifting (p<0.02) and verbal long term recall (p<0.08), indicative of frontostriatal dysfunction. Patients who underwent DBS did not demonstrate significant changes in depression, anxiety or psychological distress scores. The caseness analysis revealed that one of the patients who underwent DBS (4%) converted to dementia over 6 months compared with none of the PD controls. Conclusions: Our findings demonstrated that patients who underwent DBS experienced declines in verbal recall and trends for declines in oral information processing 6 months following surgery, even when good motor outcome was achieved. Potential candidates should be counselled about the risk of mild frontostriatal cognitive declines following DBS to weigh the risks and benefits of surgery.</abstract><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID">jnnp</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>789</start></extent></part></relatedItem><identifier type="istex">729C25B07A55F6210579AD319210C9EB9E3FB761</identifier><identifier type="DOI">10.1136/jnnp.2007.118786</identifier><identifier type="href">jnnp-79-789.pdf</identifier><identifier type="ArticleID">jn118786</identifier><identifier type="PMID">17965146</identifier><identifier type="local">jnnp;79/7/789</identifier><accessCondition type="use and reproduction" contentType="copyright">2008 BMJ Publishing Group</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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